William Clearfield, DO, HMD, FAAFRM, FAAMA
William Clearfield, DO, HMD, FAAFRM, FAAMA Medical Director, Clearfield Medical Group | Founder, The Clearfield Training Program
Dr. William Clearfield is a board-certified osteopathic physician with over four decades of experience in family, integrative, and anti-aging medicine. A graduate of LaSalle College and the College of Osteopathic Medicine and Surgery in Des Moines, IA, he has led an expansive career spanning OB/GYN, family medicine, acupuncture, and advanced endocrine therapies. He is a diplomate of the American Academy of Anti-Aging Medicine (A4M) and a Fellow of the American Academy of Medical Acupuncture (AAMA).
Dr. Clearfield pioneered the integration of hormone optimization with acupuncture and aesthetic protocols and has been at the forefront of educational initiatives, including the Clearfield Training Program—an advanced, multi-module curriculum for clinicians in anti-aging medicine. He served as editor of the Journal of Medical Acupuncture, Secretary of the AAMA, and has chaired national conferences on integrative therapies. A sought-after speaker, he lectures widely on the intersection of hormonal health, redox biology, and regenerative strategies.
In addition to his clinical work, Dr. Clearfield hosts the weekly American Osteopathic Society of Integrative Medicine Educational Webinar and maintains an active mentorship program for clinicians advancing in precision hormone care.
The Effects of Vitamin C Administration on Hormone Optimization in Clinical Practice
Regulating Eleven Endocrine Pathways Through Antioxidant Defense, Mitochondrial Support & Receptor Sensitization
Abstract
Ascorbate (Vitamin C) has long been recognized for its antioxidant, anti-inflammatory, and immunomodulatory properties. However, emerging research now reveals its far-reaching influence on endocrine regulation. This advanced lecture explores how both oral and intravenous vitamin C affect hormone synthesis, receptor sensitivity, mitochondrial signaling, and redox balance across eleven major hormonal axes.
Dr. Clearfield will review Vitamin C’s impact on testosterone, progesterone, estrogen, growth hormone, thyroid hormones and antibodies, cortisol, insulin, DHEA, pregnenolone, prolactin, and melatonin—highlighting its ability to modulate endocrine resilience in the face of aging, stress, toxicants, and metabolic dysfunction.
Clinical strategies for integrating ascorbate into hormonal protocols will be discussed, including optimal dosing, route of administration, and identification of patient subgroups most likely to benefit. This session is essential for clinicians seeking a redox-informed, systems-based approach to hormone optimization.
Learning Objectives
Upon completion of this session, participants will be able to:
- Identify the physiological mechanisms by which vitamin C modulates eleven key endocrine hormones through redox regulation, mitochondrial support, and receptor activation.
- Compare clinical strategies for oral versus intravenous vitamin C administration in hormonal optimization protocols.
- Apply evidence-based approaches to integrating vitamin C into treatment plans for thyroid, adrenal, metabolic, and reproductive hormone imbalances.
- Evaluate clinical markers, lab trends, and risk profiles to determine patient subtypes that may benefit from Vitamin C-supported endocrine therapy..
