Frank Shallenberger, MD, HMD, ABAAM
Founder, The Nevada Center for Alternative & Anti-Aging Medicine – Carson City, NV
Dr. Shallenberger is a board-certified family medicine physician and a licensed homeopathic medical doctor—one of only 16 in the state of Nevada holding dual licensure. Practicing medicine since 1973 and integrative medicine since 1978, he is a recognized pioneer in the fields of oxidative and anti-aging therapies. Dr. Shallenberger developed a breakthrough method to assess mitochondrial function and oxygen utilization, which he has detailed in his bestselling books, The Type 2 Diabetes Breakthrough and Bursting With Energy. A prolific contributor to the peer-reviewed literature on ozone therapy, he is also the long-time editor of the Second Opinion alternative medical newsletter.
Potentiating Regenerative and Ascorbate Therapy with Oxidant Stress
Abstract
This advanced-level presentation explores the clinical use of targeted oxidative stress as a regenerative and oncologic therapeutic tool. Rather than viewing oxidants as inherently damaging, Dr. Shallenberger reframes them as controlled biological signals that can activate repair pathways and improve tissue outcomes when dosed appropriately.
Key mechanisms discussed include the stimulation of growth factor release and receptor activation at specific oxidant thresholds, mitochondrial bioenergetics under redox modulation, and the synergistic integration of ozone and ascorbate therapies. The session also distinguishes between reduced ascorbate and dehydroascorbate (DHA), highlighting their divergent cellular uptake routes and implications for cancer cell cytotoxicity.
Clinicians will leave with practical insights into how oxidative therapies can be used to amplify regeneration, detoxification, and immune recalibration, particularly within integrative oncology and cellular medicine frameworks.
Learning Objectives
Upon completion of this session, participants will be able to:
- Explain the therapeutic dose range in which oxidant stress enhances regenerative processes, including growth factor signaling and receptor activation, without inducing harm.
- Differentiate between dehydroascorbate (DHA) and reduced ascorbate in terms of cellular uptake, redox effects, and their respective roles in cancer cell cytotoxicity.
- Design integrated treatment protocols that combine ozone therapy and high-dose ascorbate using timing, dose, and terrain-based strategies to enhance outcomes in regenerative and oncologic care.
