Angela Mazza, DO, ABAARM, FAAMFM, ECNU
Founder, Metabolic Center for Wellness | Oviedo, FL
Dr. Angela D. Mazza is a triple board-certified physician in Endocrinology, Diabetes & Metabolism, Internal Medicine, and Anti-Aging & Regenerative Medicine. A fellowship-trained integrative endocrinologist, she holds advanced certification in diagnostic neck ultrasound and radiofrequency ablation (RFA) through the American Association of Clinical Endocrinologists (AACE), and has earned the prestigious ECNU credential.
A published author, researcher, and podcast host, Dr. Mazza specializes in the management of autoimmune thyroid disease, thyroid nodules, and thyroid cancer. She is the founder of Central Florida’s only RFA-based thyroid nodule treatment center and has led multiple clinical trials on diabetes therapies and endocrine optimization. With a highly personalized approach, she empowers patients to improve hormonal resilience, longevity, and quality of life through evidence-based integrative strategies.
Thyroid Health & the Vitamin C Connection: Redox Balance, Autoimmunity & Endocrine Optimization
Exploring the critical role of ascorbate in thyroid hormone synthesis, inflammation control, and endocrine resilience.
Abstract
The thyroid gland plays a central role in metabolic regulation, hormonal balance, and cellular energy production. While traditionally recognized for its immune and collagen-supportive functions, Vitamin C (ascorbic acid) has emerged as a key modulator in thyroid physiology and redox homeostasis. This presentation reviews the scientific evidence linking Vitamin C to thyroid hormone synthesis, oxidative stress reduction in thyroid tissues, and modulation of autoimmune processes.
Special focus is placed on Vitamin C’s impact on adrenal-thyroid axis integrity, levothyroxine absorption, and the mitigation of environmental goitrogens. Data from clinical studies suggest that deficiencies in Vitamin C may exacerbate inflammation and oxidative damage in conditions such as Hashimoto’s thyroiditis, hypothyroidism, and Graves’ disease. Attendees will gain clinical insights into evaluating ascorbate status and implementing targeted antioxidant support in thyroid dysfunction.
Learning Objectives
Upon completion of this session, participants will be able to:
- Describe the mechanisms by which Vitamin C supports thyroid hormone synthesis, redox balance, and autoimmune modulation.
- Interpret current clinical data linking ascorbate deficiency to thyroid disorders including hypothyroidism and autoimmune thyroiditis.
- Integrate evidence-based strategies to assess and optimize Vitamin C status as part of a comprehensive thyroid care protocol.
